Endocrine Abstracts

Currently in the UK children and young people with diabetes receive variable provision of care and support in educational settings. There are concerns that this impacts on the young person’s glycaemic control, their quality of life, and their educational performance and outcome. Whilst most paediatric diabetes teams provide training for school staff, it may take several days, even weeks, after diagnosis before a diabetes educator is able to attend the school to provide ed...

BackgroundNon-classical congenial adrenal hyperplasia (NCCAH) is an important differential diagnosis in women with acne, hirsutism, menstrual abnormalities and infertility. To diagnose NCCAH can be challenging, and currently used cutoff levels are based on unstandardized immunological assays, no longer in use.ObjectiveDefine LC-MS/MS based cut-off levels for steroid hormones, to improve diagnosis of NCCAH and...

IntroductionPituitary apoplexy is a rare entity characterized by abrupt hemorrhage and/or ischaemia of the constituents of sella turcica. It usually occurs in a previously unsuspected pituitary tumor. It may have an acute or subclinical presentation and it may represent a neuroendocrinological emergency.AimThis study aims to analyze predisposing or precipitating factors, clinical status, imaging and hormonal ...

Background and objective: The purpose of this study was to retrospectively analyse the clinical, imaging and hormonal features, as well as the therapeutic outcomes in a series of consecutive patients presenting with pituitary apoplexy (PA).Design: We retrospectively reviewed 71 case-records of patients with PA admitted during 2019 in a single tertiary endocrinology center.Results: ...

Background: Saliva samples offer the possibility to obtain stress-free non-invasive samples, also for home-testing, especially useful when blood collection is either undesirable or difficult.The aim of this work was to develop an LC–MS/MS method for the determination of clinically relevant steroid hormones cortisol, cortisone, 11-deoxycortisol, 21-deoxycortisol, 17OH-progesterone, aldosterone, corticosterone, deoxycorticosterone, betamethasone, dexamethasone, testosterone...

Introduction: Acromegaly is a rare endocrinologic disease most commonly caused by an excess of growth hormone (GH) produced by a benign pituitary adenoma. Besides diverse systemic manifestations, acromegaly is also associated with a range of oral-dental problems. To date limited research has been conducted on how oral-dental pathologies affect the oral health-related quality of life (OHRQoL) in patients with acromegaly and growth hormone-producing pituitary adenomas. To our kn...

Background: Extended life expectancy and increase in neuroimaging availability, lead to increase in incidence of pituitary adenomas (PA) diagnosed after the age of 70. Recognition of PA in the elderly may be challenging and delayed due to symptoms overlapping with aging and comorbidities.Objective: To investigate character and presenting symptoms of PA in patients diagnosed after the age of 70.Methods: 105 patients (7.9%) with PA d...

Background: Increased life expectancy and wider availability of neuroimaging lead to increase in diagnosis of acromegaly in elderly patients, after the age of 70. Delay in diagnosis is attributable to milder symptomatology, higher prevalence of comorbidities and symptoms overlapping with normal aging process.Objective: To investigate clinical characteristics, presenting symptoms, comorbidities and treatment modalities of acromegaly in patients diagnosed ...

Introduction: Transcriptome analysis of peripheral blood mononuclear cells (PBMC) RNA has identified a set of androgen-responsive non-coding RNAs.Aim: To quantify the androgen-responsive gene expression and investigate its relationship to the testosterone (T) rise following hCG stimulation in boys with no genetic evidence of androgen insensitivity.Methods: Boys with suspected DSD who were evaluated at the Royal Hospital for Childre...

Introduction: Transcriptome analysis of peripheral blood mononuclear cells (PBMC) RNA has identified a set of androgen-responsive non-coding RNAs.Aim: To quantify the androgen-responsive gene expression and investigate its relationship to the testosterone (T) rise following hCG stimulation in boys with no genetic evidence of androgen insensitivity. Methods: Boys with suspected DSD who were evaluated at the Royal Hospital for Childr...